Table 2: Decreased Risk of Specific Diseases Associated With Reductions in BMI
| Magnitude of Benefit Associated With Lower BMI |
Notes on Study Population and Assumptions |
Citation to Scientific Literature |
| A reduction of one BMI unit is associated with a reduction in the probability of diabetes of 11.6% and a reduction in the probability of heart disease of 5.2%. |
Cross-sectional study of employees
and spouses in a manufacturing
company during 2001-02.
Estimates correspond to within the
BMI range of 25 to 45 kg/m2. Adjustment for age and sex. |
Wang et al.
(2006), Table 4 |
| A five-unit reduction in BMI is associated with 16% lower risk
of coronary heart disease. |
Meta-analysis of 21 published
studies. Adjustment for blood
pressure and cholesterol levels. |
Bogers et al.
(2007), Table 3 |
| A reduction of one BMI unit is associated with a 9% lower risk
of heart failure later in life. |
Framingham Heart Study.
Adjustment for age, sex, health
status, and later-life BMI. |
Lee et al. (2007),
Table 3 |
| A one-unit decrease in BMI is associated with a 14% lower risk
of sleep apnea. |
Cleveland Family Study.
Adjustment for age, gender, and
cholesterol. |
Tishler et al.
(2003), Table 5 |
| A five-unit decrease in BMI is associated with a 39% decreased
risk of colon cancer in North American men and with a 17%
decreased risk in North American women. A five-unit decrease
in BMI is associated with a 17% decreased risk of rectal
cancer in North American women (lack of studies for North
American men). |
Meta-analysis of dozens of
published studies. |
Larsson and
Wolk (2007),
Table 2 |
| A five-unit decrease in BMI is associated with a 5% lower risk
of prostate cancer in men. |
Meta-analysis of 25 published
studies. |
MacInnis and
English
(2006) |
| One-unit decrease in BMI is associated with 16% lower
probability of pancreatic cancer in men, and a 10% lower
probability of pancreatic cancer in women. |
Meta-analysis of 21 published
studies. |
Larsson,
Orsini and
Wolk (2007) |